Can Fever Be A Symptom Of Autoimmune Conditions?

In the world of health and wellness, there are countless symptoms that can arise and leave us wondering about their underlying causes. One such symptom that often leaves people curious is fever. While we commonly associate fever with infections, it may come as a surprise to learn that it can also be a symptom of autoimmune conditions. Autoimmune conditions are a group of disorders where the immune system mistakenly attacks the body’s own tissues. In this article, we will explore the connection between fever and autoimmune conditions, shedding light on the potential relationship and providing insight into what it could mean for your health.


Autoimmune conditions are disorders in which the immune system mistakenly attacks healthy cells and tissues in the body. This can lead to a wide range of symptoms and complications, including inflammation, pain, and organ damage. Fever, on the other hand, refers to an elevated body temperature that is typically a sign of an underlying infection or illness. However, there is growing evidence to suggest that fever can also be a symptom of autoimmune conditions. In this article, we will explore the connection between autoimmune conditions and fever, the autoimmune conditions associated with fever, diagnostic challenges, treatment and management, and when to seek medical help.

Autoimmune Conditions

Autoimmune conditions are a group of disorders in which the immune system mistakenly targets and attacks healthy cells and tissues in the body. This immune response can lead to chronic inflammation and damage to various organs and systems. Some common autoimmune conditions include rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and vasculitis. The exact causes of autoimmune conditions are not yet fully understood, but a combination of genetic, environmental, and hormonal factors are believed to play a role.

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Understanding Fever

Fever refers to an elevated body temperature above the normal range, which is typically around 98.6°F (37°C). It is a natural response of the body to fight off infections and illness. The body’s temperature is regulated by the hypothalamus in the brain, which acts like a thermostat. When the body detects an infection or inflammation, the hypothalamus raises the body temperature to create an inhospitable environment for the pathogen, and to stimulate the immune response. Fever can be caused by various factors, including infections, inflammation, medications, and certain autoimmune conditions.

Connection Between Autoimmune Conditions and Fever

Research has shown a strong link between autoimmune conditions and fever. The inflammatory response that occurs in autoimmune conditions can trigger an immune response, which in turn can result in fever. Fever plays an important role in the activation of the immune system by stimulating the production of immune cells and enhancing their function. Additionally, fever can help increase the production of antibodies and other proteins that fight off infections and promote healing. The mechanisms behind fever in autoimmune conditions are complex and involve the release of certain chemicals and cytokines that regulate the body’s temperature.

Autoimmune Conditions Associated with Fever

Several autoimmune conditions are commonly associated with fever. Rheumatoid arthritis, a chronic inflammatory condition that primarily affects the joints, can cause recurring low-grade fever. Systemic lupus erythematosus (SLE), a systemic autoimmune disease, often presents with fever as one of the initial symptoms. Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, can cause fever during flare-ups. Vasculitis, an inflammation of the blood vessels, can also lead to a fever. Lastly, Graves’ disease, an autoimmune disorder that affects the thyroid gland, may be accompanied by fever in some cases.

Diagnostic Challenges

Diagnosing autoimmune conditions can be challenging, particularly when fever is present. Fever alone may not be sufficient to diagnose an autoimmune condition, as it can also be a symptom of infections or other non-autoimmune illnesses. Overlapping symptoms between autoimmune conditions and infections further complicate the diagnostic process. Medical professionals must carefully evaluate a patient’s medical history, perform physical examinations, and order specific tests to differentiate fever caused by autoimmune conditions from other possible causes. The complexity of autoimmune conditions and the variability of symptoms make the diagnostic process particularly challenging.

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Treatment and Management

The treatment and management of fever in the context of autoimmune conditions rely on addressing the underlying autoimmune condition. This often involves a multifaceted approach that may include a combination of immunosuppressive medications, lifestyle changes, and self-care. Treating the autoimmune condition can help alleviate the symptoms, including fever. Symptomatic relief for fever is also an important aspect of treatment and may involve over-the-counter antipyretic medications, such as acetaminophen or ibuprofen, to reduce fever. Immunosuppressive medications may be prescribed to modulate the immune response and reduce inflammation.

When to Seek Medical Help

While fever may be a common symptom of autoimmune conditions, it is important to monitor its severity and duration. Persistent or high-grade fever that does not respond to over-the-counter medications should prompt a visit to a healthcare professional. Severe or worsening symptoms, such as intense pain, difficulty breathing, or organ dysfunction, should also trigger immediate medical attention. Regular monitoring of disease progression, especially in the case of chronic autoimmune conditions, is crucial to ensure timely intervention and appropriate management.


In conclusion, fever can indeed be a symptom of autoimmune conditions. The link between autoimmune conditions and fever lies in the inflammatory response and immune system activation that occurs in these conditions. Rheumatoid arthritis, SLE, IBD, vasculitis, and Graves’ disease are among the autoimmune conditions commonly associated with fever. However, diagnosing autoimmune conditions and managing fever can be challenging due to overlapping symptoms and the complexity of these conditions. Early detection, appropriate treatment, and regular monitoring are essential for improving outcomes and quality of life. If you experience persistent or high-grade fever or severe symptoms, it is important to seek medical advice for proper evaluation and management.